Research challenges
Ordered by how much avoidable death they cause and how tractable the next step is. Problems are chosen on evidence, never on politics.
01
Cancer: durable remission without collateral damage
Finding and testing compounds and combinations that kill tumour cells while leaving healthy tissue intact.
3 leads · 3 open questions · 1,284 contributors
02
Pneumonic plague: stopping airborne Yersinia pestis
Fast-acting therapy and field-usable diagnosis for the lung form of plague, where untreated death comes within days.
3 leads · 3 open questions · 416 contributors
03
Antibiotic resistance: refilling an empty pipeline
Mining natural products and overlooked chemistry for antibacterials that resistant strains have never met.
2 leads · 2 open questions · 702 contributors
04
Sepsis: catching the cascade before organ failure
Earlier detection signals and interventions that interrupt the inflammatory cascade in time.
2 leads · 2 open questions · 389 contributors